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Job Location: Philadelphia, PA
The Ocular Pre-Clinical Research Lead will manage the Ocular functional group within the Research department. He/she will be responsible for:
Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.
Initiate and oversee joint programs with academic collaborators.
Establishing project timelines and ensuring work is completed according to schedule.
Training and developing staff at varying levels of experience.
The Ocular Pre-Clinical Research Lead position requires extensive translational experience with ocular gene therapies, including:
In-depth knowledge of inherited retinal disorders is required.
Experience with animal models of inherited retinal disorders and use of AAV gene therapy to treat these disorders is required.
Experience with functional and structural endpoint measurements, such as ERG, optokinetic analysis, imaging, etc.
Experience with intraocular delivery techniques
Familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for ophthalmic gene therapy.
Some knowledge of clinical trial design and regulatory strategy is preferred.
20% Hands-on execution of experiments on the bench
50% Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
10% Prioritize projects, plan workload, manage resource and personnel scheduling
10% Preparing sample analysis reports and write parts of regulatory submissions to FDA
10% Lead a team of scientists. Mentor and develop staff.
Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
Prioritize projects, plan workload, manage resource and personnel scheduling
Preparing sample analysis reports and write parts of regulatory submissions to FDA
Lead a team of scientists. Mentor and develop staff.
Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
Extensive hands-on experience in ocular gene therapy, such as intravitreal and subretinal injections, and measurement of ophthalmic efficacy and safety endpoints
Strong organizational skills.
Excellent writing and verbal communication skills.
Previous management experience preferred, but not required.
Strong publication record is a plus.
Experience with AAV vectors is a plus.
Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark
Exercise judgment within defined procedures and practices to determine appropriate action.
Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Development, R&D Operations, Technical Operations, Regulatory Affairs, Executive Team.
Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.)
Minimum 5-8 years of hands-on experience in the field of ophthalmic gene therapy
Previous management or supervisory experience strongly preferred
WHO WE ARE:
Transforming Patients Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.
How To Apply:
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