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Analytical Development Scientist
Spark Therapeutics, Inc
Job Location: Philadelphia, PA
Under general guidance from the Analytical Development Lead, working closely with colleagues in R&D and Quality Control, the successful candidate will develop, optimize and qualify analytical methods for use in gene therapy product characterization. Specifically, the candidate will develop chromatographic and electrophoresis methods to provide critical knowledge about AAV-based vectors. S/he will provide written and oral updates to project teams, provide support for regulatory document filings, provide technical reports and data summaries and participate in technology transfer.

This is a hands-on laboratory-based position in a fast-paced, dynamic environment. S/he must be able to contribute to the delivery of corporate goals under aggressive timelines.

  • Chromatography and/or electrophoresis method optimization, qualification and technology transfer.
  • Data review; project updates; technical report and SOP preparation.

  • The candidate must possess strong oral presentation and scientific writing skills, as demonstrated in peer-reviewed publications and scientific meeting oral presentations/posters.

  • PhD or MS in Biotechnology, Biochemistry or related field.
  • Minimum 1-3 years (PhD) or 4-7 years (MS) of relevant biotech industry experience working in a laboratory setting is required.
  • Experience with chromatography method development is required. Experience with capillary electrophoresis method development is strongly preferred.
  • Experience in biophysical characterization, such as mass spectrometry, analytical ultracentrifugation, dynamic light scattering, and/or electron microscopy is strongly preferred.
  • Experience with gene therapy and viral vector products in a GMP/GLP laboratory setting is strongly preferred but not required.
  • Experience writing SOPs and technical documents is required.


Transforming Patients Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.


How To Apply:
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